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While radiological and upper motor neuron findings can support the diagnosis, overdependence on these features may postpone necessary intervention

Long-term nutritional deprivation compromises growth, while from a developmental perspective, decreased insulin signaling (leading to GHR uncoupling) prolongs life (at least in some experimental animal models) which ensures that fertile age is reached, and survival of the species is ensured

When this enzyme shuts down, the methylation cycle stalls, leading to a vicious cycle where the body cannot produce the very antioxidants (like glutathione, which relies on downstream methylation pathways) needed to clear the viral-induced oxidative stress

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